Product Name | [Val5] Angiotensin II, human |
Product Quantity | 10mg |
Catalog Number | LT0785 |
Molecular Weight | 1032.18 |
Formula | C49H69N13O12 |
Sequence | Asp-Arg-Val-Tyr-Val-His-Pro-Phe |
Product Description | The octapeptide angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Ang II is formed by cleavage of Ang I by the angiotensin-converting enzyme (ACE) or chymases. The biological activities of angiotensin II include the regulation of blood pressure, salt and water balance, and vascular tonus. |
Scientific Background | [Val5] Angiotensin II, human is a synthetic research peptide in the angiotensin peptide family. The renin-angiotensin system generates bioactive peptides by sequential proteolysis. Angiotensin I is converted by ACE to angiotensin II, while shorter metabolites such as angiotensin III and angiotensin IV have distinct receptor and enzymatic contexts. Exact residue numbering is therefore essential. |
Research Applications | - ACE substrate and inhibition studies
- angiotensin receptor assays
- renin-angiotensin processing studies
- fragment structure-activity comparisons
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Experimental Notes | The exact sequence, residue range, species, terminal state, and chemical modifications should be matched to the intended assay. Fragmentation or processing can materially alter receptor selectivity, potency, aggregation, or enzymatic behavior. |
Selected References | - Angiotensin peptide processing literature
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