Product Description | Tuftsin comprises residues 289-292 of the Fc domain in the heavy chain of immunoglobulin G. Tuftsin is a physiologically active tetrapeptide with immunoadjuvant properties including the stimulation of macrophage and granulocyte phagocytosis, migration, bactericidal, and tumoricidal activities. It also inhibits vascular endothelial growth factor (VEGF) by binding neurophilin-1 (NP-1). This peptide has been found to reduce EAE symptoms in mice. |
Scientific Background | Tuftsin is a synthetic research peptide in the tuftsin immunomodulatory peptide family. Tuftsin is the tetrapeptide Thr-Lys-Pro-Arg, derived from the Fc region of immunoglobulin G. It has long been used as an immunomodulatory peptide associated with stimulation of phagocytic cell functions, and more recent work identified neuropilin-1 as a receptor involved in tuftsin signaling in macrophage/microglial systems. |
Experimental Notes | The exact sequence, isoform, residue substitutions, amidation, stereochemistry, labels, and other chemical modifications can change activity substantially. For receptor-activating peptides and membrane-active peptides, concentration and assay format are especially important and should be matched to the intended experimental system. |
