Tuftsin

Tuftsin comprises residues 289-292 of the Fc domain in the heavy chain of immunoglobulin G. Tuftsin is a physiologically active tetrapeptide with immunoadjuvant properties including the stimulation of macrophage and granulocyte phagocytosis, migration, bactericidal, and tumoricidal activities. It also inhibits vascular endothelial growth factor (VEGF) by binding neurophilin-1 (NP-1). This peptide has been found to reduce EAE symptoms in mice.