Tetanus toxin (TT) peptide

Tetanus toxin (TT) peptide is a synthetic research peptide in the tetanus toxin-derived T-cell peptide family. Tetanus toxin contains multiple human CD4 T-cell epitopes that have been mapped using overlapping synthetic peptides. Defined tetanus-toxin peptides are commonly used as helper-T-cell epitopes, antigen-presentation controls, carrier-helper components, and positive controls in cellular immune assays. Individual peptide recognition is HLA-dependent, and the exact toxin residue range should be matched to the relevant published epitope.

• CD4 T-cell stimulation assays
• helper-T-cell epitope studies
• antigen-presentation controls
• peptide-carrier immunology experiments
• T-cell proliferation assays

For antigenic peptides, MHC/HLA restriction, species, viral strain or tumor-antigen isoform, residue numbering, sequence substitutions, and chemical modifications can materially affect peptide binding and cellular recognition. The exact construct should therefore be matched to the intended assay and the reference sequence used in the experimental system.

1. Identification of two promiscuous T-cell epitopes from tetanus toxin
2. Mapping the major human T-helper epitopes of tetanus toxin with synthetic peptides