Substance P (6-11)

Substance P(6-11) represents the C-terminal tachykinin pharmacophore and retains receptor-related activity. It is useful for structure-activity analysis of NK1 receptor recognition and tachykinin signaling.

• neuropeptide receptor pharmacology
• GPCR signaling
• neuroendocrine and smooth-muscle studies
• structure-activity research

Terminal pyroglutamate, amidation and exact residue boundaries are part of the reagent identity and should be retained when comparing tachykinin or bombesin-family activity.

1. Selected peer-reviewed publication