Substance P (1-9)

Substance P(1-9) is a fragment of Subtance P. Evidence shows that N- and C-terminal substance P fragments have significant biological activity. Substance P(1-9) has been reported to be major substance P metabolites in rat striatum and it has modulatory effects similar to substance P.

Substance P (1-9) is a synthetic research peptide in the tachykinin neuropeptide family. Substance P, neurokinin A, and neurokinin B are mammalian tachykinins that preferentially interact with NK1, NK2, and NK3 receptors, respectively. Their shared C-terminal tachykinin motif is important for receptor activation, while N-terminal truncation, substitutions, and labels can alter affinity, selectivity, and stability.

• tachykinin receptor binding and activation assays
• NK1/NK2/NK3 pharmacology
• calcium or phospholipase signaling studies
• fragment and analog structure-activity comparisons

The exact sequence, species, residue range, terminal state, labels, stereochemistry, and post-translational modifications should be considered when comparing this reagent with the native peptide. Receptor potency and assay behavior should be validated in the intended experimental system.

1. Mammalian tachykinin receptor pharmacology
2. Tachykinin peptide/receptor selectivity