Product Description | Substance P (1-4) is a fragment which is hydrolyzed from substance P by a prolyl endopeptidase. It seems to stabilize substance P against proteolytic degradation, to modulate the activity of substance P on various tissues, to exert a stimulatory effect on phagocytes and to release histamine from mast cells. Substance P 1-4 fragment is critical for mast cell activation. Replacement of the N terminal sequence of bradykinin with the aa 1-4 of Substance P (RPKP) enhanced the inhibitory activity of bradykinin on aminopeptidases |
Scientific Background | Substance P (1-4) is a synthetic research peptide in the tachykinin neuropeptide family. Substance P, neurokinin A, and neurokinin B are mammalian tachykinins that preferentially interact with NK1, NK2, and NK3 receptors, respectively. Their shared C-terminal tachykinin motif is important for receptor activation, while N-terminal truncation, substitutions, and labels can alter affinity, selectivity, and stability. |
Experimental Notes | The exact sequence, species, residue range, terminal state, labels, stereochemistry, and post-translational modifications should be considered when comparing this reagent with the native peptide. Receptor potency and assay behavior should be validated in the intended experimental system. |
