Product Name | [Ser140]-Myelin Proteolipid Protein (139-151) (Depalmitoylated) |
Product Quantity | 0.5mg |
Catalog Number | LT12003 |
Molecular Weight | 1521.74 |
Formula | C72H104N20O17 |
Sequence | HSLGKWLGHPDKF |
Purity | >95% |
Product Description | HSLGKWLGHPDKF, {HIS}{SER}{LEU}{GLY}{LYS}{TRP}{LEU}{GLY}{HIS}{PRO}{ASP}{LYS}{PHE}, Myelin proteolipid protein is the major myelin protein from the central nervous system (CNS). It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Myelin proteolipid protein is a highly conserved hydrophobic protein of 276 to 280 amino acids which seems to contain four transmembrane segments, two disulphide bonds and which covalently binds lipids (at least six palmitate groups in mammals). PLP is highly related to M6, a neuronal membran glycoprotein. |
Scientific Background | [Ser140]-Myelin Proteolipid Protein (139-151) (Depalmitoylated) is a synthetic research peptide in the myelin proteolipid protein PLP(139-151) peptide category. PLP(139-151) is a major encephalitogenic myelin proteolipid protein epitope in SJL/J mice and is widely used to induce and study relapsing experimental autoimmune encephalomyelitis. Published mapping studies identified residues within this region as sufficient for encephalitogenic T-cell activity. Palmitoylation state or residue substitutions can change the properties of an individual construct. |
Research Applications | - PLP(139-151)-induced EAE studies
- autoreactive CD4 T-cell assays
- myelin antigen-presentation experiments
- tolerance and epitope-structure studies
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Experimental Notes | The exact supplied sequence and modification state should be used when interpreting published results. Activity reported for a parent peptide, labeled derivative, formulation, species variant, or related analog should not automatically be assigned to this construct. |
Selected References | - PLP 139-151 as the major encephalitogen for relapsing EAE in SJL/J mice
- Minimum sequence requirements of the PLP 139-151 encephalitogenic region
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