Product Description | Secretin is a hormone that controls the secretions into the duodenum, and also separately, water homeostasis throughout the body. It is produced in the S cells of the duodenum in the crypts of Lieberkühn. Its effect is to regulate the pH of the duodenal contents via the control of gastric acid secretion and buffering with bicarbonate from the centroacinar cells of the pancreas as well as intercalated ducts. Human secretin also potentiates the release of digestive enzymes from the pancreas triggered by cholecystokinin. |
Scientific Background | Secretin, human is a synthetic research peptide in the secretin peptide family. Secretin is a linear 27-residue hormone and the natural ligand for the secretin receptor, a prototypic class B GPCR. Its C-terminal region contributes receptor binding while the N terminus is critical for receptor activation and Gs-mediated cAMP signaling. |
Experimental Notes | The exact sequence, residue range, species, terminal state, and chemical modifications should be matched to the intended assay. Fragmentation or processing can materially alter receptor selectivity, potency, aggregation, or enzymatic behavior. |
