RSV M (187 - 195)

RSV M (187 - 195) is a synthetic research peptide in the respiratory syncytial virus (RSV)-derived peptide family. Respiratory syncytial virus contains experimentally defined CTL epitopes used to study antiviral T-cell responses. The M2 protein includes the immunodominant H-2Kd-restricted peptide spanning residues 82-90 (SYIGSINNI), and other RSV matrix-derived peptides are used for residue-specific epitope mapping and comparative antigen-recognition studies. The exact protein, residue range, and MHC context determine the relevance of each synthetic RSV peptide.

• RSV-specific T-cell assays
• viral epitope mapping
• MHC-restricted CTL studies
• peptide stimulation controls
• antiviral immune-response research

For antigenic peptides, MHC/HLA restriction, species, viral strain or tumor-antigen isoform, residue numbering, sequence substitutions, and chemical modifications can materially affect peptide binding and cellular recognition. The exact construct should therefore be matched to the intended assay and the reference sequence used in the experimental system.

1. Identification of an immunodominant RSV M2 CTL epitope by peptide immunization