R-G-D-C

Surfaces modified with RGDC were shown to be effective for osteoblast binding and proliferation. RGDC binds via its sulfhydryl moiety to gold particles and gold-coated implants increasing the biocompatibility of the latter. The surface of titanium implants has to be modified beforehand to allow covalent S binding.

R-G-D-C is a 4-residue synthetic peptide with the sequence Arg-Gly-Asp-Cys. The sequence contains 1 cysteine residue, providing potential thiol/disulfide chemistry when the thiol is available. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

• thiol-selective conjugation or immobilization studies
• LC-MS/HPLC analytical method development
• sequence-specific assay controls

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.