Human growth hormone (HGH) is a 191 amino acid non-glycosylated protein hormone secreted by the anterior pituitary gland in brain. It is one of the most important postnatal hormones. HGH plays an important role in cell proliferation, bone formation, muscle strength, organogenesis and somatic growth because its principal physiological functions are the stimulation on the rate of protein synthesis and the mobilization and utilization of fatty acids, and decline on the rate of carbohydrate utilization.
Recombinant human growth hormone is a protein that is manufactured to be nearly identical to the main form of the naturally occurring human growth hormone. This hormone can stimulate tissue growth, linear growth (height), and protein, carbohydrate, lipid, and mineral metabolism. It has approved indications in both the adult and pediatric populations. In the United States, recombinant human growth hormone is used in the pediatric population to treat short stature due to growth hormone deficiency (including idiopathic [of unknown cause] growth hormone deficiency), Turner syndrome, Noonan syndrome, Prader-Willi syndrome, short stature homeobox-containing gene (SHOX) deficiency, chronic renal insufficiency, idiopathic short stature and children small for gestational age.
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