Rat Renin FRET Substrate, FAM/QXL520

An internally quenched substrate designed for rat renin. Renin initiates the renin-angiotensin system by cleaving angiotensinogen to generate angiotensin I. Renin-mediated cleavage separates QXL520 from 5-FAM and restores fluorescence near 490/520 nm.

• rat renin activity assays
• renin-angiotensin system research
• renin inhibitor screening
• cardiovascular enzyme studies

This sequence is a rat-renin assay reagent and should not automatically substitute for the human-renin substrate. The vendor technical sheet reports a molecular-weight range, retained here rather than estimated.

1. Structure-based design of aliskiren, a novel orally effective renin inhibitor