[Pyr3]-Amyloid Beta-Protein (3-42)

[Pyr3]-Amyloid Beta-Protein (3-42) is a synthetic research peptide in the amyloid-beta family. The listed sequence/design is Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala. Amyloid-beta peptides are widely used to study aggregation, oligomerization, fibril formation, sequence-dependent conformational behavior, and analytical detection relevant to Alzheimer disease research. Pyroglutamate-modified Aβ species have been reported to show altered oligomerization, aggregation, and proteolytic stability compared with unmodified Aβ.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. On the seeding and oligomerization of pGlu-amyloid peptides (PMID 17029395).
2. Pyroglutamate-modified amyloid beta(3-42) monomer study (PMID 37306611).