Product Name | Neurotensin, guinea pig |
Product Quantity | 10mg |
Catalog Number | LT1918 |
Molecular Weight | 1662.92 |
Formula | C76H119N21O21 |
Sequence | Pyr-Leu-Tyr-Glu-Asn-Lys-Ser-Arg-Arg-Pro-Tyr-Ile-Leu |
Product Description | Neurotensin is a brain and gastrointestinal peptide is a 13 amino acid neuropeptide. Neurotensin has been suggested to be involved in neurological and mental disorders associated with altered dopaminergic transmission. High-affinity Neurotensin binding sites are present in the guinea-pig brain in regions rich in both dopamine cell bodies and terminals. Neurotensin facilitates release of substance P in the guinea-pig inferior mesenteric ganglion. |
Scientific Background | Neurotensin, guinea pig is a synthetic research peptide in the neurotensin peptide family. Neurotensin is an endogenous 13-residue neuropeptide acting principally through neurotensin receptors NTS1 and NTS2. Its C-terminal region contains key determinants for receptor interaction, so full-length neurotensin, fragments, substitutions, and labeled derivatives are useful for receptor-binding and structure-activity studies. |
Research Applications | - NTS1/NTS2 receptor assays
- neurotensin binding studies
- fragment structure-activity comparisons
- neuropeptide signaling research
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Experimental Notes | The exact sequence, residue range, species, terminal state, stereochemistry, labels, and other modifications can alter receptor affinity or biological activity. Match the supplied construct to the intended experimental system and reference sequence. |
Selected References | - Neurotensin and its analogues
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