Myelin Oligodendrocyte Glycoprotein (35-55), rat MOG (35-55)

Myelin-oligodendrocyte glycoprotein (MOG) is a single, non-glycosylated polypeptide chain containing 21 amino acids and having a molecular mass of 2582 Dalton, is a minor component of the myelin sheath. MOG is also a CNS-specific autoantigen for primary demyelination in multiple sclerosis. The developmentally late expression of MOG correlates with the later stages of myelogenesis, suggesting that MOG has a role in the completion, compaction and maintenance of myelin. MOG has many isoforms that can form homo- and heterodimers. It has been shown that the MOG(35-55)peptide induced anti-MOG(35-55) autoantibody production in C57BL/6 mice with 100% incident (10/10), providing quantitative support for the suitability of the MOG peptide for in vivo anti-MOG(35-55) autoantibody study.