Myelin Oligodendrocyte Glycoprotein (35-55), rat MOG (35-55)

Myelin-oligodendrocyte glycoprotein (MOG) is a single, non-glycosylated polypeptide chain containing 21 amino acids and having a molecular mass of 2582 Dalton, is a minor component of the myelin sheath. MOG is also a CNS-specific autoantigen for primary demyelination in multiple sclerosis. The developmentally late expression of MOG correlates with the later stages of myelogenesis, suggesting that MOG has a role in the completion, compaction and maintenance of myelin. MOG has many isoforms that can form homo- and heterodimers. It has been shown that the MOG(35-55)peptide induced anti-MOG(35-55) autoantibody production in C57BL/6 mice with 100% incident (10/10), providing quantitative support for the suitability of the MOG peptide for in vivo anti-MOG(35-55) autoantibody study.

Myelin Oligodendrocyte Glycoprotein (35-55), rat MOG (35-55) is a synthetic research peptide in the myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide family. MOG(35-55) is a widely used encephalitogenic peptide in H-2b mouse models of experimental autoimmune encephalomyelitis. The peptide is used to study autoreactive T-cell responses, CNS inflammation, demyelination, immune tolerance, and EAE disease mechanisms. Species sequence and residue numbering should be verified for each construct.

• MOG(35-55)-induced EAE models
• autoreactive T-cell assays
• CNS autoimmunity studies
• immune-tolerance experiments

The exact sequence, residue range, species, stereochemistry, terminal state, labels, and other modifications can materially affect activity. Match the supplied construct to the intended assay and published reference context.

1. MOG peptide induces chronic EAE in H-2b mice
2. MOG(35-55) EAE protocol and model