Product Name | Leucokinin I |
Product Quantity | 10mg |
Catalog Number | LT1737 |
Molecular Weight | 891.93 |
Formula | C41H52N11O12 |
Sequence | Asp-Pro-Ala-Phe-Asn-Ser-Trp-Gly-NH2 |
Product Description | The leucokinins are small insect neuropeptides which were originally isolated from head extracts of the Madeira cockroach, Leucophaea maderae. They stimulate the contractions of the cockroach's lower digestive tract. |
Scientific Background | Leucokinin I is a synthetic research peptide in the leucokinin / insect kinin peptide family. Leucokinins are insect neuropeptides that signal through kinin/leucokinin GPCRs and participate in regulation of water balance, feeding, gut physiology, and related neuroendocrine functions. Functional receptor studies have demonstrated dose-dependent activation by leucokinin peptides, while genetic manipulation of the signaling system alters physiological and behavioral phenotypes in insects. |
Research Applications | - leucokinin receptor activation assays
- insect osmoregulation studies
- feeding and gut-physiology research
- neuropeptide GPCR structure-function experiments
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Experimental Notes | Species, isoform, residue range, amidation state, stereochemistry, and other modifications can materially affect receptor affinity and biological response. The exact construct should therefore be matched to the intended assay and published reference context. |
Selected References | - Functional identification and characterization of leucokinin and its receptor in the fall webworm
- Leucokinin-like peptide receptor function in the cattle fever tick
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