Human Integrin alpha A1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (LTP10165)

Product Name
Human Integrin alpha A1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (LTP10165)
Catalog Number
LTP10165
Quantity
100ug
Price
$563 In stock
Background
Integrin ?1?1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen?binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin ?1?1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
Description
Recombinant Human Integrin alpha A1 beta 1 (ITGA1&ITGB1) Heterodimer Protein is expressed from Expi293 with His tag at the C-terminal. It contains Phe29-Pro1141(ITGA1)&Gln21-Asp728(ITGB1).
Target
Integrin alpha A1 beta 1 (ITGA1&ITGB1) Heterodimer
Species
Human
Gene/Protein ID
P56199-1(ITGA1)&P05556(ITGB1)
Exact Sequence
Phe29-Pro1141(ITGA1) & Gln21-Asp728(ITGB1)
Molecular Weight
The protein has a predicted MW of 129.1 kDa(ITGA1)&83.2 kDa(ITGB1). Due to glycosylation, the protein migrates to 160-200 kDa based on the Tris-Bis PAGE result.
Activity
0
Tag
C-His
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in 50 mM Tris, 150 mM NaCl (pH 7.5). Normally 8% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

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Human Integrin alpha A1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (LTP10165)
  • 5 Units in Stock

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