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| Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein (LTP10872) |
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| LTP10872 |
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| 100ug |
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$563 In stock |
| Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling |
| Recombinant Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Phe24-Gly1012(ITGA6) acidic tail&GIn21-Asp728(ITGB1) basic tail. |
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| Integrin ITGA6&ITGB1 Heterodimer |
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| Human |
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| P23229-2(ITGA6)&P05556-1(ITGB1) |
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| Phe24-Gly1012(ITGA6)acidic tail & GIn21-Asp728(ITGB1)basic tail |
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| The protein has a predicted MW of 117.9 kDa(ITGA6)&83.2 kDa(ITGB1). Due to glycosylation, the protein migrates to 110-130 kDa based on the Tris-Bis PAGE result. |
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| 0 |
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| C-His-Avi |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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