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| Human GPVI Protein (LTP10406) |
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| LTP10406 |
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| 100ug |
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$406 In stock |
| Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands. |
| Recombinant Human GPVI Protein is expressed from Expi293 with His tag at the C-terminal. It contains Gln21-Lys267. |
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| GPVI |
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| Human |
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| Q9HCN6-1 |
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| Gln21-Lys267 |
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| The protein has a predicted MW of 28 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human GPVI, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-GPVI Antibody, hFc Tag with the EC50 of 14.8ng/ml determined by ELISA. See testing image for detail. |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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