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| Human Clusterin Protein (LTP10269) |
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| LTP10269 |
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| 100ug |
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$406 In stock |
| Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. It plays important roles in protein homeostasis/proteostasis, inhibition of cell death pathways, and modulation of pro-survival signalling and transcriptional networks. Changes in the CLU gene locus are highly associated with Alzheimer disease, and many therapy-resistant cancers over-express CLU. |
| Recombinant Human Clusterin Protein is expressed from Expi293 with His tag at the C-terminal. It contains Asp23-Glu449. |
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| Clusterin |
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| Human |
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| P10909-1 |
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| Asp23-Glu449 |
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| The protein has a predicted MW of 51.2 kDa. The protein migrates to 38-41 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human Clusterin, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-Clusterin Antibody, hFc Tag with the EC50 of 49.2ng/ml determined by ELISA. See testing image for detail. |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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