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| Human CD96/TACTILE Protein (LTP10245) |
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| LTP10245 |
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| 100ug |
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$519 In stock |
| The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development. |
| Recombinant Human CD96/TACTILE Protein is expressed from Expi293 with His tag at the C-terminal. It contains Val22-Met503. |
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| CD96/TACTILE |
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| Human |
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| P40200-2 |
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| Val22-Met503 |
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| The protein has a predicted MW of 54.7 kDa. Due to glycosylation, the protein migrates to 115-130 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human CD96, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-CD96 Antibody, hFc Tag with the EC50 of 0.17ug/ml determined by ELISA (QC Test). The affinity constant of 0.958 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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