Histone H4 (8-30)-WGK(Biotin)

Histone H4(8-30)-WGK(Biotin) is an N-terminally acetylated internal H4 fragment centered on Lys20 and terminated with a WG linker plus biotinylated lysine. It provides an immobilizable reference ligand for H4K20 methylation-state studies.

• H4K20 reader binding
• streptavidin pull-down assays
• histone methylation controls
• chromatin protein studies

The N-terminal acetyl group, WG linker and biotinylated lysine are part of the exact construct. This unmodified Lys20 reference should be compared with matched K20Me1/2/3 variants.

1. Degrees make all the difference: the multifunctionality of histone H4 lysine 20 methylation