Histone H3 (73-83)

Histone H3(73-83) is a minimal internal fragment centered on Lys79. Lys79 methylation is catalyzed by DOT1L in the context of nucleosomes and is involved in transcriptional regulation and DNA-damage responses.

• H3K79 recognition studies
• DOT1L-related research
• histone antibody controls
• internal H3 epitope mapping

This peptide is a sequence-defined H3K79-centered reagent, but DOT1L catalytic activity is strongly nucleosome dependent; peptide-only assays should therefore be interpreted accordingly.

1. Histone H3K79 methylation and the DNA damage response