HCV Core Protein (107-114)

HCV Core Protein (107-114) is a synthetic hepatitis C virus-derived antigenic peptide. HCV-derived peptides from core and nonstructural proteins are widely used to map CD8-positive and CD4-positive T-cell responses. Synthetic peptides have been used to define HLA-restricted CTL epitopes, examine sequence variation and immune escape, and quantify antigen-specific responses. The immunological properties of each reagent depend on its exact viral region, sequence, genotype or strain, and restricting HLA allele.

• HCV-specific T-cell assays
• HLA-restricted CTL epitope mapping
• immune-escape variant studies
• helper-T-cell experiments
• viral sequence comparison

For antigenic or viral peptides, HLA restriction, cellular response, and immunological activity should not be inferred solely from the source protein name; the exact sequence, residue numbering, strain or genotype, and experimental system should be considered. For labeled or otherwise modified variants, the modification may also affect binding or assay behavior.

1. An HCV core epitope recognized by human and murine cytotoxic T lymphocytes
2. Hepatitis C virus-specific cytotoxic T lymphocytes and synthetic peptide-defined epitopes