GRP (14-27) (human, porcine,canine)

GRP (14-27) (human, porcine, canine) is a synthetic research peptide in the bombesin / gastrin-releasing peptide (GRP) family. Bombesin and mammalian gastrin-releasing peptide are members of the bombesin-like peptide family and are used extensively in GRP-receptor research. Their C-terminal region contains key determinants for receptor binding and activation, making terminal fragments, substitutions, and modified analogs useful tools for defining GRPR recognition, agonism/antagonism, internalization, and structure-activity relationships.

• receptor-binding
• competition assays
• functional signaling assays
• enzymatic-processing or stability studies
• antibody controls
• LC-MS/HPLC method development
• comparative structure-activity experiments

For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, and stability should be considered when selecting reconstitution and assay conditions.

1. Minimal ligand analysis of gastrin releasing peptide
2. Molecular basis of the selectivity of gastrin-releasing peptide receptor for mammalian bombesin peptides