gp100 (639–647)

gp100 (639–647) is a synthetic gp100/PMEL melanocyte antigen peptide. gp100 (also known as PMEL/gp100) is a melanocyte-lineage protein that contains multiple experimentally defined MHC-restricted T-cell epitopes. Synthetic gp100 peptides have been used to identify cytotoxic T-lymphocyte epitopes, quantify peptide-specific T-cell responses, investigate HLA-binding anchor substitutions, and compare native versus affinity-enhanced antigenic peptides. The HLA restriction and T-cell recognition of any individual product depend on its exact sequence.

• HLA-peptide binding studies
• melanoma antigen-specific T-cell assays
• CTL epitope mapping
• tetramer or immune-monitoring controls
• native-versus-modified epitope comparisons

For antigenic or viral peptides, HLA restriction, cellular response, and immunological activity should not be inferred solely from the source protein name; the exact sequence, residue numbering, strain or genotype, and experimental system should be considered. For labeled or otherwise modified variants, the modification may also affect binding or assay behavior.

1. Recognition of multiple epitopes in the human melanoma antigen gp100
2. Improved induction of melanoma-reactive CTL with modified gp100 peptides