GLP-1 (1-37) (human, bovine,guinea pig, mouse, rat)

GLP-1 (1-37) (human, bovine, guinea pig, mouse, rat) is a synthetic research peptide in the GLP/glucagon-family family. The listed sequence/design is His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly. GLP-family peptides are used in glucagon-family receptor and incretin research. Published GLP-1 structure-activity studies show that both N-terminal and C-terminal regions contribute to receptor binding and signaling.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Structure-activity relationships of GLP-1(7-36)amide (PMID 8138751).
2. High potency antagonists of the pancreatic GLP-1 receptor (PMID 9261127).