[Gln18]-Platelet Factor 4 (15-22) (human)

[Gln18]-Platelet Factor 4 (15-22) (human) is a synthetic research peptide in the platelet factor 4-derived peptide family. Platelet factor 4 (CXCL4) is a platelet chemokine with a lysine-rich C-terminal heparin-binding region. Synthetic PF4 fragments including residues 58-70 have been used to investigate heparin interaction, neutrophil responses, angiogenesis, and the contribution of the C-terminal domain to PF4 activity.

• heparin-binding studies
• PF4 fragment structure-function studies
• neutrophil response assays
• angiogenesis-related peptide research

The exact sequence, residue range, stereochemistry, cyclization, terminal state, species, and chemical modifications can materially affect activity. The supplied construct should be matched to the intended assay and the specific literature context.

1. Structural requirements of platelet factor 4 peptides for neutrophil activation
2. Inhibition of angiogenesis by platelet factor-4-derived peptides