Product Name | Ghrelin (Rat) |
Product Quantity | 5mg |
Catalog Number | LT1483 |
Molecular Weight | 3314.8 |
Formula | C147H245N45O42 |
Sequence | Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro- Arg |
Product Description | The growth hormone releasing peptide Ghrelin (rat) corresponds to aa 24-51 of the 117 amino acid Ghrelin (rat) precursor. The 28-amino acid n-octanoylated (at ser3) natural peptidyl ligand for the growth hormone secretagogue receptor 1a (GHSR1a). Ghrelin is secreted predominantly in the stomach and stimulates growth hormone release from the pituitary gland. |
Scientific Background | Ghrelin (Rat) is a synthetic research peptide in the ghrelin / proghrelin-derived peptide family. Ghrelin is a 28-residue peptide hormone and endogenous ligand for the growth hormone secretagogue receptor GHS-R1a. Native bioactive ghrelin carries an essential n-octanoyl modification at Ser3; unacylated, precursor-derived, truncated, or otherwise modified ghrelin peptides should therefore not be assumed to reproduce the receptor activity of acyl-ghrelin. |
Research Applications | - GHS-R1a receptor assays
- ghrelin structure-activity studies
- growth-hormone secretagogue research
- proghrelin processing studies
- acylated versus non-acylated peptide comparisons
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Experimental Notes | The exact sequence, species, residue range, terminal state, labels, stereochemistry, and post-translational modifications should be considered when comparing this reagent with the native peptide. Receptor potency and assay behavior should be validated in the intended experimental system. |
Selected References | - Discovery of ghrelin as an acylated GHS-R ligand
- Ghrelin receptor nomenclature, distribution, and function
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