Product Name | Ghrelin (human) |
Product Quantity | 5 mg, >90% purity |
Catalog Number | LT1482 |
Molecular Weight | 3370.9 |
Formula | C149H249N47O42 |
Sequence | Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg, Serine 3 residue is n-octanoylated |
Product Description | Human ghrelin (GHR), the endogenous ligand of the growth hormone secretagogue receptor (GHS-R), potently stimulates GH release. The side-chain octanoyl (capryloyl) ester of Ser3 is essential for the activity of the peptide. Ghrelin plays an important role in the short-term regulation of appetite and in the long-term regulation of energy balance and glucose homeostasis. |
Scientific Background | Ghrelin (human) is a synthetic research peptide in the ghrelin / proghrelin-derived peptide family. Ghrelin is a 28-residue peptide hormone and endogenous ligand for the growth hormone secretagogue receptor GHS-R1a. Native bioactive ghrelin carries an essential n-octanoyl modification at Ser3; unacylated, precursor-derived, truncated, or otherwise modified ghrelin peptides should therefore not be assumed to reproduce the receptor activity of acyl-ghrelin. |
Research Applications | - GHS-R1a receptor assays
- ghrelin structure-activity studies
- growth-hormone secretagogue research
- proghrelin processing studies
- acylated versus non-acylated peptide comparisons
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Experimental Notes | The exact sequence, species, residue range, terminal state, labels, stereochemistry, and post-translational modifications should be considered when comparing this reagent with the native peptide. Receptor potency and assay behavior should be validated in the intended experimental system. |
Selected References | - Discovery of ghrelin as an acylated GHS-R ligand
- Ghrelin receptor nomenclature, distribution, and function
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