Product Description | Galanin is widely distributed throughout the rat neural and endocrine system. The highest concentrations are found in the anterior pituitary. Galanin has different activities such as contraction of smooth muscle of the gastrointestinal and genito-urinary tract, regulation of growth hormone and insulin release, and control of adrenal secretion. |
Scientific Background | Galanin, rat is a synthetic research peptide in the galanin family. Galanin is a 29/30-residue neuroendocrine peptide that acts through galanin receptors. Its N-terminal region is an important determinant of receptor interaction, and synthetic fragments and analogs have been used to examine receptor subtype pharmacology, peptide conformation, membrane association, and the structural requirements for galanin signaling. |
Experimental Notes | For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, and stability should be considered when selecting reconstitution and assay conditions. |
