[Des-octanoyl]-Ghrelin, human

[Des-octanoyl]-Ghrelin, human is a synthetic research peptide in the ghrelin family. Ghrelin is an acylated peptide hormone that activates the growth-hormone secretagogue receptor (GHSR). The unusual acyl modification at Ser3 is a critical structural determinant for native ghrelin receptor activation, while N-terminal residues contain much of the minimal receptor-activating information. Ghrelin fragments, des-acyl forms, acyl variants, and substituted analogs are used to probe receptor recognition and structure-activity relationships.

• receptor-binding
• competition assays
• functional signaling assays
• enzymatic-processing or stability studies
• antibody controls
• LC-MS/HPLC method development
• comparative structure-activity experiments

For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, and stability should be considered when selecting reconstitution and assay conditions.

1. Structure-function studies on the growth hormone-releasing peptide ghrelin
2. Molecular recognition of an acyl-peptide hormone and activation of the ghrelin receptor