[Des-Gly10,Dleu6, ProNHEt9]?LH-RH?Leuprolide

[Des-Gly10, Dleu6, ProNHEt9]?LH-RH?Leuprolide is a synthetic research peptide in the gonadotropin-releasing hormone (GnRH/LH-RH) peptide family. GnRH is a hypothalamic decapeptide acting through the GnRH receptor. Synthetic GnRH analogs such as leuprolide incorporate substitutions and terminal modifications that increase stability or modify receptor pharmacology. Native LH-RH, species variants, and analogs are useful for receptor, structure-activity, and analytical studies.

• GnRH receptor assays
• GnRH analog structure-activity studies
• species-variant comparisons
• analytical peptide reference work

The exact sequence, residue range, stereochemistry, cyclization, terminal state, species, and chemical modifications can materially affect activity. The supplied construct should be matched to the intended assay and the specific literature context.

1. Development and pharmacology of GnRH analogs including leuprolide
2. Cyclic and stabilized GnRH analog structure-activity studies