[D-Ala2]- Beta-Casomorphin (1-5) amide (bovine)

[D-Ala2]- Beta-Casomorphin (1-5) amide (bovine) is a synthetic research peptide in the beta-casomorphin / milk-derived opioid peptide family. Beta-casomorphins are opioid-active peptides derived from beta-casein. Beta-casomorphin-7 is a well-studied member and can interact with opioid receptors; experimentally, BCM-7 has been shown to influence intestinal mucin secretion through opioid-receptor-dependent pathways. Sequence length, stereochemistry, and residue substitutions can substantially alter opioid activity and stability.

• opioid receptor binding and competition assays
• intestinal or epithelial signaling studies
• peptide digestion and stability studies
• comparative structure-activity experiments
• LC-MS/HPLC analytical reference work

For fragments, substituted analogs, labeled peptides, stereochemical variants, or terminally modified forms, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, oxidation, and stability should be considered when establishing reconstitution, storage, and assay conditions.

1. beta-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a mu-opioid pathway
2. Formation and Degradation of Beta-casomorphins in Dairy Processing