C-terminal Proghrelin Isoform Peptide, mouse

C-terminal Proghrelin Isoform Peptide, mouse is a synthetic research peptide in the ghrelin / proghrelin-derived peptide family. Ghrelin is a 28-residue peptide hormone and endogenous ligand for the growth hormone secretagogue receptor GHS-R1a. Native bioactive ghrelin carries an essential n-octanoyl modification at Ser3; unacylated, precursor-derived, truncated, or otherwise modified ghrelin peptides should therefore not be assumed to reproduce the receptor activity of acyl-ghrelin.

• GHS-R1a receptor assays
• ghrelin structure-activity studies
• growth-hormone secretagogue research
• proghrelin processing studies
• acylated versus non-acylated peptide comparisons

The exact sequence, species, residue range, terminal state, labels, stereochemistry, and post-translational modifications should be considered when comparing this reagent with the native peptide. Receptor potency and assay behavior should be validated in the intended experimental system.

1. Discovery of ghrelin as an acylated GHS-R ligand
2. Ghrelin receptor nomenclature, distribution, and function