Scientific Background | Biotinyl-MCH (salmon) is a synthetic research peptide in the melanin-concentrating hormone (MCH) peptide family. Melanin-concentrating hormone is a cyclic neuropeptide that activates MCH receptors. The human MCH receptor was molecularly characterized as a G-protein-coupled receptor responsive to nanomolar MCH, and subsequent mutagenesis/analog studies identified Arg11 of MCH as a critical determinant for receptor binding and activation. MCH fragments, substitutions, and related pro-MCH peptides are useful for receptor pharmacology and sequence-function analysis. |
Experimental Notes | For fragments, substituted analogs, labeled peptides, stereochemical variants, or terminally modified forms, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, oxidation, and stability should be considered when establishing reconstitution, storage, and assay conditions. |
