Biotin-[Glu1]-Gastrin I (human) (phosphorylated)

Biotin-[Glu1]-Gastrin I (human) (phosphorylated) is a synthetic research peptide in the gastrin / cholecystokinin (CCK) family. Gastrin and cholecystokinin are structurally related gastrointestinal peptide hormones that act at CCK receptor subtypes. The conserved C-terminal region is especially important for biological activity, while sulfation state, terminal processing, residue substitutions, and fragment length can alter CCK1/CCK2 receptor affinity and functional response. Synthetic variants are therefore useful for receptor pharmacology and structure-activity studies.

• receptor-binding
• competition assays
• functional signaling assays
• enzymatic-processing or stability studies
• antibody controls
• LC-MS/HPLC method development
• comparative structure-activity experiments

For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, and stability should be considered when selecting reconstitution and assay conditions.

1. On the biologically active structures of cholecystokinin and gastrin peptides
2. Characterization of two novel cholecystokinin tetrapeptide agonists