Biotin-Atrial Natriuretic Peptide (1-28), human,porcine

Atrial natriuretic peptide (ANP), is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. ANP has been found to protect against reoxygenation-induced hypercontracture in isolated cardiomyocytes by increasing cyclic guanosine monophosphate synthesis; ANP also contributes to stimulation of lipolysis during repeated bouts of exercise and in the control of lipolysis during exercise. ANP is a potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis, it has a cGMP-stimulating activity.

Biotin-Atrial Natriuretic Peptide (1-28), human,porcine is a 30-residue synthetic peptide with the sequence Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-Cys-Cys. Biotin provides an affinity handle for streptavidin-based capture or detection. The sequence contains 4 cysteine residues, providing potential thiol/disulfide chemistry when the thiol is available; contains 0 Lys and 5 Arg residues, contributing cationic character; contains 3 aromatic residues that can contribute to hydrophobic or aromatic interactions. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

• streptavidin-based capture or detection
• binding and pull-down assay development
• thiol-selective conjugation or immobilization studies
• LC-MS/HPLC analytical method development
• sequence-specific assay controls

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.