Product Name | Beta-MSH, human |
Product Quantity | 5mg |
Catalog Number | LT2515 |
Molecular Weight | 2660.9 |
Formula | C118H174N34O35S |
Sequence | Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp |
Product Description | The melanocyte-stimulating hormones (collectively referred to as MSH or intermedins) are a class of peptide hormones that in nature are produced by cells in the intermediate lobe of the pituitary gland. They stimulate the production and release of melanin (melanogenesis) by melanocytes in skin and hair. Beta-MSH (melanocyte stimulating hormone) is capable of activating melanocortin-4 receptor and inhibiting feeding. |
Scientific Background | Beta-MSH, human is a synthetic research peptide in the melanocyte-stimulating hormone / melanocortin peptide family. Melanocyte-stimulating hormone peptides are POMC-derived melanocortin ligands. Residues around the His-Phe-Arg-Trp pharmacophore are important for melanocortin-receptor activation, and substitutions such as D-Phe7 or Nle4 can markedly increase potency or alter receptor selectivity. Exact fragment length, cyclization, and terminal modifications should therefore be considered when interpreting analog activity. |
Research Applications | - melanocortin receptor binding assays
- MC1R-MC5R signaling studies
- MSH analog structure-activity comparisons
- POMC-derived peptide research
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Experimental Notes | The exact sequence, residue range, stereochemistry, cyclization, terminal state, species, and chemical modifications can materially affect activity. The supplied construct should be matched to the intended assay and the specific literature context. |
Selected References | - Discovery of prototype melanocortin agonists using NDP-MSH
- Molecular basis for interaction of NDP-MSH with melanocortin receptors
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