Beta-Amyloid (9-42)

Aβ(9-42) is an N-terminally truncated 42-residue-ending amyloid-beta species. N-terminally truncated Aβ variants have been identified in plaque-derived material and provide useful reagents for comparing how truncation affects aggregation and biochemical behavior.

• amyloid-beta aggregation research
• Alzheimer's disease research
• structure-function studies
• sequence-fragment controls

N-terminal truncation and fragment boundaries can substantially change solubility, metal binding and aggregation behavior. This exact sequence should therefore be treated as a distinct research reagent rather than substituted with full-length Aβ.

1. Relative abundance of Alzheimer Aβ amyloid peptide variants in Alzheimer disease and normal aging