Beta-Amyloid (3-42), pyroGlu3

Pyroglutamate Aβ3-42 begins with cyclized Glu3 and lacks the first two native Aβ residues. N-terminal pyroglutamate Aβ species are found in Alzheimer-associated deposits and show altered proteolytic stability and aggregation behavior relative to unmodified Aβ.

• amyloid-beta aggregation research
• Alzheimer disease research
• sequence/control studies
• biochemical assay development

Exact fragment boundaries, sequence order and N-terminal chemistry can materially alter Aβ solubility, aggregation and recognition. Treat this construct as a distinct reagent and use matched controls.

1. Pyroglutamate and isoaspartate modified amyloid-beta in ageing and Alzheimer's disease