Beta-Amyloid (1-42), HiLyte Fluor 488-Labeled

HiLyte Fluor 488-Aβ(1-42) is a green fluorescent derivative of the highly aggregation-prone Aβ(1-42) peptide. It has been used extensively to examine Aβ uptake, clearance, fibrillogenesis and cellular localization.

• Aβ(1-42) aggregation
• microglial uptake and clearance
• live-cell amyloid imaging
• autophagy and trafficking studies

Aβ(1-42) is strongly preparation-dependent. Fluorescent labeling can change aggregation behavior; avoid repeated freeze-thaw cycles and use matched unlabeled controls.

1. How Fluorescent Tags Modify Oligomer Size Distributions of the Alzheimer Peptide
2. Direct Observations of Amyloid β Self-Assembly in Live Cells