Amylin (8-37), human

Amylin (8-37), human is a synthetic research peptide in the amylin / islet amyloid polypeptide family. Amylin, also known as islet amyloid polypeptide, belongs to the calcitonin peptide family and signals through amylin receptor complexes formed by the calcitonin receptor with receptor-activity-modifying proteins. Human amylin is also strongly amyloidogenic. Amylin fragments and analogs are useful for receptor pharmacology, peptide aggregation, amyloid formation, sequence-function, and comparative species studies.

• receptor or ligand-binding assays
• competition studies
• biochemical or enzymatic assays
• analytical LC-MS/HPLC methods
• antibody controls
• cell-based experiments
• comparative structure-activity studies

For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, oxidation, and stability should be considered when establishing reconstitution, storage, and assay conditions.

1. A structural basis for amylin receptor phenotype
2. Molecular signature for receptor engagement in the amylin peptide family