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Alpha-Synuclein (123-132)-MiniPEG3-KKK Peptide is derived from the canonical 140-amino-acid human alpha-synuclein protein encoded by SNCA. The sequence corresponds to residues 123-132 of the public UniProtKB P37840 alpha-synuclein sequence.
Alpha-Synuclein Biology
Alpha-synuclein is a neuronal protein associated with presynaptic vesicles and is studied extensively in synaptic biology, membrane interaction, protein aggregation, and neurodegenerative disease research. The canonical human protein contains 140 amino acids.
The N-terminal region contains repeated KTKEGV-like motifs and can adopt amphipathic helices upon membrane binding. The central hydrophobic region contributes to fibril formation, while the C-terminal region is acidic, disordered, and rich in sites for protein interaction and post-translational modification.
Fragment Location: Residues 123-132
This fragment lies in the acidic C-terminal region of alpha-synuclein, which is highly charged and frequently studied in protein-interaction, antibody, and post-translational-modification experiments.
Special Feature of LT8716
The MiniPEG3-KKK extension provides a hydrophilic spacer and lysine-rich tail useful for assay or conjugation design.
Research Applications
- Alpha-synuclein antibody epitope mapping
- ELISA and binding assays
- Protein-peptide interaction studies
- Aggregation-related research
- Post-translational modification studies
- Assay controls and standards
Canonical Human Alpha-Synuclein Sequence Source
The complete 140-residue human sequence is publicly curated in UniProtKB entry P37840. The peptide sequence in LT8716 is a contiguous fragment of that canonical sequence, with the indicated research modification where applicable.
References
UniProt Consortium SNCA - Alpha-synuclein - Homo sapiens. UniProtKB P37840.
Public source / publication Related LifeTein Services
Custom Peptide Synthesis
Fluorescent Peptide Labeling
Peptide Click Chemistry and Conjugation
Peptide Carrier Protein Conjugation
Research Use Only. Not for human, diagnostic, clinical, or therapeutic use.
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