Alpha-Synuclein (122-140) C-Terminal Peptide

Alpha-Synuclein (122-140) C-Terminal Peptide is derived from the canonical 140-amino-acid human alpha-synuclein protein encoded by SNCA. The sequence corresponds to residues 122-140 of the public UniProtKB P37840 alpha-synuclein sequence.

Alpha-Synuclein Biology

Alpha-synuclein is a neuronal protein associated with presynaptic vesicles and is studied extensively in synaptic biology, membrane interaction, protein aggregation, and neurodegenerative disease research. The canonical human protein contains 140 amino acids.

The N-terminal region contains repeated KTKEGV-like motifs and can adopt amphipathic helices upon membrane binding. The central hydrophobic region contributes to fibril formation, while the C-terminal region is acidic, disordered, and rich in sites for protein interaction and post-translational modification.

Fragment Location: Residues 122-140

This fragment lies in the acidic C-terminal region of alpha-synuclein, which is highly charged and frequently studied in protein-interaction, antibody, and post-translational-modification experiments.

Special Feature of LT8714

This product provides a defined synthetic alpha-synuclein fragment for sequence-specific biochemical and immunochemical studies.

Research Applications

• Alpha-synuclein antibody epitope mapping
• ELISA and binding assays
• Protein-peptide interaction studies
• Aggregation-related research
• Post-translational modification studies
• Assay controls and standards

Canonical Human Alpha-Synuclein Sequence Source

The complete 140-residue human sequence is publicly curated in UniProtKB entry P37840. The peptide sequence in LT8714 is a contiguous fragment of that canonical sequence, with the indicated research modification where applicable.

References

UniProt Consortium SNCA - Alpha-synuclein - Homo sapiens. UniProtKB P37840.
Public source / publication

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Research Use Only. Not for human, diagnostic, clinical, or therapeutic use.

Alpha-Synuclein (122-140) C-Terminal Peptide is a 19-residue synthetic peptide with the sequence Asn-Glu-Ala-Tyr-Glu-Met-Pro-Ser-Glu-Glu-Gly-Tyr-Gln-Asp-Tyr-Glu-Pro-Glu-Ala. The sequence contains 1 Asp and 6 Glu residues, contributing anionic character near neutral pH; contains 3 aromatic residues that can contribute to hydrophobic or aromatic interactions. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

• LC-MS/HPLC analytical method development
• sequence-specific assay controls

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.