Product Description | This neuropeptide was isolated from the corpora cardiaca of the corn earworm moth, Heliothis zea. Adipokinetic hormones (AKHs) are metabolic neuropeptides, mediating mobilization of energy substrates from the fat bodies of many insects. They bring on the release of diglycerides and then stimulate the flight muscles to use them as an energy source. |
Scientific Background | Adipokinetic Hormone, AKH, locust is a synthetic research peptide in the adipokinetic hormone (AKH) peptide family. Adipokinetic hormones are insect neuropeptides that mobilize stored energy reserves during metabolically demanding activities such as flight. AKH-family peptides act through cognate G-protein-coupled receptors, and species-specific AKH sequences have been characterized across insects. Comparative peptide/receptor studies are useful for examining ligand selectivity, energy-mobilization signaling, and structural diversity within the AKH/RPCH family. |
Experimental Notes | The exact sequence, reporter group, phosphorylation state, stereochemistry, and terminal modifications should be considered when comparing this reagent with the parent peptide or published assay substrates. Enzyme concentration, buffer composition, cofactors, pH, ionic strength, and substrate concentration can also affect measured activity. |
