Product Name | Ac-Endothelin-1 (16-21),human |
Product Quantity | 10mg |
Catalog Number | LT0838 |
Molecular Weight | 837.98 |
Formula | C41H59N9O10 |
Sequence | Ac-His-Leu-Asp-Ile-Ile-Trp |
Product Description | ET-1 is a potent vasoconstrictor peptide, derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes. |
Scientific Background | Ac-Endothelin-1 (16-21),human is a 6-residue synthetic peptide with the sequence His-Leu-Asp-Ile-Ile-Trp. N-terminal acetylation neutralizes the terminal alpha-amino group. The sequence has a relatively high hydrophobic-residue fraction that can influence aqueous solubility and surface adsorption. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - LC-MS/HPLC analytical method development
- sequence-specific assay controls
|
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
