Ac-a-CGRP (19-37) (human)

Ac-a-CGRP (19-37) (human) is a synthetic research peptide in the calcitonin gene-related peptide (CGRP) family. Calcitonin gene-related peptide is a 37-residue neuropeptide that activates the canonical CGRP receptor formed by calcitonin receptor-like receptor (CLR) and RAMP1. Structure-activity work has shown that the N-terminal disulfide ring is important for agonist activity, while the C-terminal region contributes strongly to receptor binding. CGRP fragments and substitutions are widely used to distinguish agonist, antagonist, and receptor-binding determinants.

• CGRP receptor binding and cAMP assays
• vascular and neuropeptide signaling studies
• agonist/antagonist structure-activity experiments
• CLR/RAMP1 receptor pharmacology
• analytical peptide standards

For fragments, substituted analogs, labeled peptides, stereochemical variants, or terminally modified forms, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, oxidation, and stability should be considered when establishing reconstitution, storage, and assay conditions.

1. Structure-activity relationships for alpha-calcitonin gene-related peptide
2. Pharmacological characterization of novel alpha-CGRP receptor peptide antagonists