Product Name | VPM peptide: GCRDVPMSMRGGDRCG |
Catalog Number | LT255422 |
Sequence | GCRDVPMSMRGGDRCG, NH2- Gly - Cys - Arg - Asp - Val - Pro - Met - Ser - Met - Arg - Gly - Gly - Asp - Arg - Cys - Gly -COOH |
Purity | >95% |
Size | 5 mg |
Catalog # | LT255422 |
Storage | -20°C |
Product Description | 
VPM peptide, GCRDVPMSMRGGDRCG, a cysteine-containing biodegradable matrix metalloproteinase (MMP) crosslinker peptide, is an enzyme-cleavable sequence and can be incorporated into hydrogel backbones to give synthetic hydrogels the capacity to be proteolytically degraded by cell-secreted enzymes. The peptide can be used to study cell migration and matrix remodeling. |
Scientific Background | VPM peptide: GCRDVPMSMRGGDRCG is a 16-residue synthetic peptide with the sequence Gly-Cys-Arg-Asp-Val-Pro-Met-Ser-Met-Arg-Gly-Gly-Asp-Arg-Cys-Gly. C-terminal amidation removes the terminal carboxylate charge. The sequence contains 2 cysteine residues, which can support thiol-selective conjugation or disulfide chemistry when the thiol group is available; is enriched in basic residues (0 Lys and 3 Arg), giving the sequence a cationic character under many aqueous conditions. No specific receptor, enzyme, pathway, disease association, or biological activity is assigned to this peptide without product-specific experimental evidence. |
Research Applications | - thiol-selective conjugation or immobilization studies
- LC-MS/HPLC analytical method development
- sequence-specific assay controls
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Experimental Notes | Sequence-derived chemical properties are provided to support reagent selection and experimental planning. They do not establish a biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
