VIP Receptor-Binding Inhibitor L-8-K

VIP Receptor-Binding Inhibitor L-8-K is a synthetic research peptide in the VIP family. The listed sequence/design is Leu-Met-Tyr-Pro-Thr-Tyr-Leu-Lys. VIP is a class B GPCR peptide ligand that acts at VPAC1 and VPAC2 receptors and is structurally related to PACAP. Synthetic VIP fragments and analogs are used in receptor-binding and signaling studies.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Characterization of intestinal receptors for VIP and PACAP (PMID 11193817).